Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC016
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-13 11:28
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 250mg3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 13, 'TP': 22, 'FP': 17}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 17.796
timePerCircleCoV 0.16992
timePerCircleSlope -0.0425972
meanError 1.32477
tremorFreq 5.66406
tremorRelPower 30.7384
tremorGyroAmpMean 0.0196749
tremorGyroAmpSlope -0.00134579
tremorGyroAmpCoV 0.389909
tremorCoordAmpMean 0.0290234
tremorCoordAmpSlope -0.000318478
tremorCoordAmpCoV 0.304492
tremorAccAmpMean 0.0801793
tremorAccAmpSlope -0.000104172
tremorAccAmpCoV 0.0562382
tremorPcRelVar 0.600007
tremorPcX -0.2236
tremorPcY -0.974681

Circle Segment 1

Duration 21.68 s, Accuracy Estimate 1.314 (lower is better)

Circle Segment 2

Duration 18.84 s, Accuracy Estimate 1.055 (lower is better)

Circle Segment 3

Duration 21.04 s, Accuracy Estimate 0.904 (lower is better)

Circle Segment 4

Duration 22.56 s, Accuracy Estimate 1.184 (lower is better)

Circle Segment 5

Duration 15.16 s, Accuracy Estimate 1.12 (lower is better)

Circle Segment 6

Duration 16.72 s, Accuracy Estimate 1.303 (lower is better)

Circle Segment 7

Duration 14.36 s, Accuracy Estimate 1.052 (lower is better)

Circle Segment 8

Duration 16.96 s, Accuracy Estimate 1.606 (lower is better)

Circle Segment 9

Duration 15.2 s, Accuracy Estimate 1.123 (lower is better)

Circle Segment 10

Duration 15.44 s, Accuracy Estimate 2.586 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 44.3933
timePerSpiralCoV 0.142658
timePerSpiralSlope -0.0689164
meanError 1.86526
tremorFreq 5.66406
tremorRelPower 28.5754
tremorGyroAmpMean 0.0221026
tremorGyroAmpSlope 0.000673379
tremorGyroAmpCoV 0.396942
tremorCoordAmpMean 0.0426319
tremorCoordAmpSlope 0.00413503
tremorCoordAmpCoV 1.5314
tremorAccAmpMean 0.0811235
tremorAccAmpSlope 0.000162625
tremorAccAmpCoV 0.0693488
tremorPcRelVar 0.656599
tremorPcX 0.232423
tremorPcY -0.972615

Spiral Segment 1

Duration 52.96 s, Accuracy Estimate 2.097 (lower is better)

Spiral Segment 2

Duration 48.28 s, Accuracy Estimate 1.785 (lower is better)

Spiral Segment 3

Duration 48.2 s, Accuracy Estimate 2.021 (lower is better)

Spiral Segment 4

Duration 37.72 s, Accuracy Estimate 1.727 (lower is better)

Spiral Segment 5

Duration 41.48 s, Accuracy Estimate 1.798 (lower is better)

Spiral Segment 6

Duration 37.72 s, Accuracy Estimate 1.763 (lower is better)

Elel

eDurationMean 0.864211
eDurationStd 0.241732
eDurationStdnorm 0.279715
eDurationMedian 0.805
eDurationQuartdelta 0.27
eDurationQuartdeltanorm 0.335404
eDurationKurt 4.53324
eDurationTrenddiff -0.27
eDurationTrendratio 0.717277
eWidthMean 4.91708
eWidthStd 1.173
eWidthStdnorm 0.238555
eWidthMedian 4.914
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.309524
eWidthKurt 5.2053
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 9.81876
eHeightStd 3.7543
eHeightStdnorm 0.38236
eHeightMedian 9.5355
eHeightQuartdelta 3.978
eHeightQuartdeltanorm 0.417178
eHeightKurt 4.02382
eHeightTrenddiff 0.117
eHeightTrendratio 1.01235
eAspectMean 0.566292
eAspectStd 0.240883
eAspectStdnorm 0.425368
eAspectMedian 0.501857
eAspectQuartdelta 0.2061
eAspectQuartdeltanorm 0.410675
eAspectKurt 4.58951
eAspectTrenddiff -0.0149917
eAspectTrendratio 0.970582
eSlantMean -0.164775
eSlantStd 0.288468
eSlantStdnorm -1.75068
eSlantMedian -0.0822535
eSlantQuartdelta 0.361345
eSlantQuartdeltanorm -4.39306
eSlantKurt 3.26318
eSlantTrenddiff -0.0982143
eRtopMean 0.609274
eRtopStd 0.204834
eRtopStdnorm 0.336193
eRtopMedian 0.624837
eRtopQuartdelta 0.242424
eRtopQuartdeltanorm 0.38798
eRtopKurt 2.72108
eRtopTrenddiff 0.0156318
eRbotMean 0.873736
eRbotStd 0.388452
eRbotStdnorm 0.444588
eRbotMedian 0.822917
eRbotQuartdelta 0.434487
eRbotQuartdeltanorm 0.527984
eRbotKurt 4.08277
eRbotTrenddiff 0.166667
eRrightMean 0.678351
eRrightStd 0.217541
eRrightStdnorm 0.32069
eRrightMedian 0.716732
eRrightQuartdelta 0.298696
eRrightQuartdeltanorm 0.416747
eRrightKurt 2.5938
eRrightTrenddiff -0.0853534
eRleftMean 0.495908
eRleftStd 0.145002
eRleftStdnorm 0.292398
eRleftMedian 0.47902
eRleftQuartdelta 0.239286
eRleftQuartdeltanorm 0.499532
eRleftKurt 2.35808
eRleftTrenddiff -0.0272996
lDurationMean 0.975541
lDurationStd 0.302916
lDurationStdnorm 0.310511
lDurationMedian 0.89
lDurationQuartdelta 0.22
lDurationQuartdeltanorm 0.247191
lDurationKurt 4.78808
lDurationTrenddiff -0.12
lDurationTrendratio 0.876607
lWidthMean 7.14965
lWidthStd 2.52716
lWidthStdnorm 0.353466
lWidthMedian 7.02
lWidthQuartdelta 2.6325
lWidthQuartdeltanorm 0.375
lWidthKurt 3.29299
lWidthTrenddiff 2.2815
lWidthTrendratio 1.39394
lHeightMean 25.6673
lHeightStd 3.29814
lHeightStdnorm 0.128496
lHeightMedian 24.921
lHeightQuartdelta 4.3875
lHeightQuartdeltanorm 0.176056
lHeightKurt 2.81084
lHeightTrenddiff 3.744
lHeightTrendratio 1.15881
lAspectMean 0.27577
lAspectStd 0.0807007
lAspectStdnorm 0.292637
lAspectMedian 0.267677
lAspectQuartdelta 0.0977579
lAspectQuartdeltanorm 0.365209
lAspectKurt 2.95488
lAspectTrenddiff 0.0574051
lAspectTrendratio 1.23014
lSlantMean -0.0250884
lSlantStd 0.110295
lSlantStdnorm -4.39626
lSlantMedian -0.0409091
lSlantQuartdelta 0.122581
lSlantQuartdeltanorm -2.99641
lSlantKurt 2.52966
lSlantTrenddiff 0.0348047
lRtopMean 0.789669
lRtopStd 0.109634
lRtopStdnorm 0.138836
lRtopMedian 0.816667
lRtopQuartdelta 0.142497
lRtopQuartdeltanorm 0.174486
lRtopKurt 4.74202
lRtopTrenddiff -0.0527619
lRbotMean 1.00704
lRbotStd 0.532137
lRbotStdnorm 0.528417
lRbotMedian 0.9
lRbotQuartdelta 0.525018
lRbotQuartdeltanorm 0.583354
lRbotKurt 4.97563
lRbotTrenddiff -0.201488
lRrightMean 0.879646
lRrightStd 0.087222
lRrightStdnorm 0.0991558
lRrightMedian 0.9
lRrightQuartdelta 0.0620886
lRrightQuartdeltanorm 0.0689873
lRrightKurt 5.20657
lRrightTrenddiff -0.0322279
lRleftMean 0.438475
lRleftStd 0.173589
lRleftStdnorm 0.395893
lRleftMedian 0.454545
lRleftQuartdelta 0.23811
lRleftQuartdeltanorm 0.523841
lRleftKurt 2.46731
lRleftTrenddiff -0.0989638

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.982041
sumTouchScores 11.7845
meanMovementTime 1.44091
numTouches 12
undershootPercentage 0
overshootPercentage 8.33333

FITTS Long Modified

meanTouchScore 0.876871
sumTouchScores 10.5225
meanMovementTime 1.43364
numTouches 12
undershootPercentage 8.33333
overshootPercentage 8.33333

ZigZag

numZigzags 5
timePerZigzagMean 32.144
timePerZigzagCoV 0.102663
timePerZigzagSlope -0.0614734
meanError 1.92922
tremorFreq 5.95703
tremorRelPower 25.533
tremorGyroAmpMean 0.0238795
tremorGyroAmpSlope 0.00115928
tremorGyroAmpCoV 0.37969
tremorCoordAmpMean 0.0393585
tremorCoordAmpSlope -0.000829744
tremorCoordAmpCoV 0.287766
tremorAccAmpMean 0.0291391
tremorAccAmpSlope -0.00129671
tremorAccAmpCoV 0.321422
tremorPcRelVar 0.697799
tremorPcX 0.0883567
tremorPcY -0.996089

ZigZag Segment 1

Duration 34.92 s, Accuracy Estimate 1.562 (lower is better)

ZigZag Segment 2

Duration 35.6 s, Accuracy Estimate 2.079 (lower is better)

ZigZag Segment 3

Duration 32.68 s, Accuracy Estimate 1.944 (lower is better)

ZigZag Segment 4

Duration 29.36 s, Accuracy Estimate 1.858 (lower is better)

ZigZag Segment 5

Duration 28.16 s, Accuracy Estimate 2.203 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.112
timePerZigzagCoV 0.15195
timePerZigzagSlope -0.0874253
zigzagHeightMean 87.9471
zigzagHeightCoV 0.055163
zigzagHeightSlope -0.0260394
meanError 0.0528228
tremorFreq 6.05469
tremorRelPower 27.8425
tremorGyroAmpMean 0.0345181
tremorGyroAmpSlope 0.00372065
tremorGyroAmpCoV 0.371118
tremorCoordAmpMean 0.0530576
tremorCoordAmpSlope 0.00356706
tremorCoordAmpCoV 0.331566
tremorAccAmpMean 0.0438284
tremorAccAmpSlope 0.00289025
tremorAccAmpCoV 0.278018
tremorPcRelVar 0.738568
tremorPcX -0.136905
tremorPcY 0.990584

ZigZag Offset Segment 1

Duration 27.36 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 2

Duration 26.96 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 3

Duration 25.96 s, Accuracy Estimate 0.072 (lower is better)

ZigZag Offset Segment 4

Duration 19.96 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 5

Duration 20.32 s, Accuracy Estimate 0.055 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.32}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.2091864917002333}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9382097684273865}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8015260902824735}